NaturaCel Research and Clinical Studies

Studies on Alpha Lipoic Acid

Background:
alpha-lipoic acid (LA) or the reduced form dihydrolipoate (DHLA) is a potent scavenger with anti-inflammatory properties. Previous uncontrolled studies with topical treatment with 5% LA-containing creams indicate a beneficial effect on photoageing skin.

Objective:
The purpose of this study was to investigate whether a cream containing 5% LA showed any advantages concerning a number of the criteria associated with ageing of the facial skin, compared with an identical cream lacking LA.

Material and methods:
Thirty-three women, mean age 54.4 years, were included in this controlled study. After randomization half the face was treated twice daily for 12 weeks with the LA cream and the other half with the control cream. The following methods of assessment were used: self-evaluation by the test subjects, clinical evaluation, photographic evaluation and laser profilometry. Profilometry was performed before the start of treatment and at the end.

Results:
All four methods of assessment showed a statistically significant improvement on the LA-treated half of the face. Laser profilometry, the most objective method used, showed an average decrease in skin roughness of 50.8% (44.9-54.0) on the LA-treated side, compared with 40.7% (32.4-48.7) on the placebo-treated half of the face P < 0.001 (Wilcoxon matched pairs test).

Conclusions:
It is indicated that 12 weeks of treatment with a cream containing 5% LA improves clinical characteristics related to photoageing of facial skin.

Source: http://www.ncbi.nlm.nih.gov/pubmed/14616378
Department of Dermatology, Karolinska Hospital, 17176 Stockholm, Sweden.


Other Studies on Alpha Lipoic Acid
  1. Beitner H. Randomized, placebo controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol. 2003;149:841-9.
  2. Clark WM, Rinker LG, Lessov NS, Lowery SL, Cipolla MJ. Efficacy of antioxidant therapies in transient focal ischemia in mice. Stroke. 2001;32(4):1000-1004.
  3. Lynch MA. Lipoic acid confers protection against oxidative injury in non-neuronal and neuronal tissue. Nutr Neurosci. 2001;4(6):419-438.
  4. Nagamatsu M, Nickander KK, Schmelzer JD,et al. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care. 1995;18:1160-1167.
  5. Packer L, Kraemer K, Rimbach G. Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition. 2001;17(10):888-895.
  6. Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant alpha-linoic acis. Free Radic Biol Med. 1997;22:359-378.
  7. Packer L, Witt EH, Tritschler HJ. Alpha-lipoic acid as a biological antioxidant. Free Rad Bio Med. 1995;19(2):227-250.
  8. Panigrahi M, Sadguna Y, Shivakumar BR, Kolluri SV, Roy S, Packer L, Ravindranath V. Alpha-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats. Brain Res. 1996;717(1-2):184-188.
  9. Rakel D. Rakel Integrative Medicine, 2nd ed. Philadelphia, Pa: Elsevier Inc. 2008;84.
  10. Segermann J, Hotze A, Ulrich H, et al. Effect of alpha-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. Arzneimittelforschung. 1991;41:1294-1298.
  11. Alpha-lipoic acid | University of Maryland Medical Center
    http://umm.edu/health/medical/altmed/supplement/alphalipoic-acid#ixzz38OWMjH6j University of Maryland Medical Center


Studies of Resveratrol
  1. Baxter RA. Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation. J Cosmet Dermatol. 2008 Mar;7(1):2-7.
  2. Aziz MH, Afaq F, Ahmad N. Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin. Photochem Photobiol. 2005 Jan-Feb; 81(1):25-31.
  3. Afaq F, Mukhtar H. Botanical antioxidants in the prevention of photocarcinogenesis and photoaging. Exp Dermatol. 2006 Sept; 15(9):678-84.
  4. Adhami VM, Afaq F, Ahmad N. Suppression of ultraviolet B exposure-mediated activation of NF-kappaB in normal human keratinocytes by resveratrol. Neoplasia. 2003 Jan-Feb;5(1):74-82.
  5. Chen ML, Li J, Xiao WR, et al. Protective effect of resveratrol against oxidative damage of UVA irradiated HaCaT cells. Jhong Nan Da Xue Xue Bao Yi Ban. 2006 Oct; 31(5):635-Available at: http://www.everypatent.com/comp/pat6147121.html. Accessed August 2, 2011.
  6. Gawlik M, Czajka A. The effect of green, black and white tea on the level of alpha and gamma tocopherols in free radical induced oxidative damage of human red blood cells. Acta Pol Pharm. 2007 Mar-Apr;64(2):159-64.
  7. Borawska MH, Czechowska SK, Markiewicz R, Hayirli A, Olszewska E, Sahin K. Cell viability of normal human skin fibroblast and fibroblasts derived from granulation tissue: effects of nutraceuticals. J Med Food. 2009 Apr; 12(2):429-34.
  8. du Toit R, Volsteedt Y, Apostolides Z. Comparison of the antioxidant content of fruits, vegetables and teas measured as vitamin C equivalents. Toxicology. 2001 Sep 14;166(1-2):63-9.
  9. Wha Kim S, Lee IW, Cho HJ, et al. Fibroblasts and ascorbate regulate epidermalization in reconstructed human epidermis. J Dermatol Sci. 2002 Dec;30(3):215-23.
  10. Bell E, Rosenberg M, Kemp P, et al. Recipes for reconstituting skin. J Biomech Eng. 1991 May;113(2):113-9.
  11. Chepda T, Cadau M, Lassabliere F, et al. Synergy between ascorbate and alpha-tocopherol on fibroblasts in culture. Life Sci. 2001 Aug 24;69(14):1587-96.
  12. Dorozhko AI, Brodskii AV, Afanas'ev IB. Chelating and antiradical effect of rutin during peroxidation of lipids from microsomes and liposomes. Biokhimiia. 1988 Oct;53(10):1660-6.
  13. Available at: http://www.antioxidants-for-health-and-longevity.com/how-do-antioxidants-work.html. Accessed July 26, 2011.
  14. Shindo Y, Witt E, Han D, Epstein W, Packer L. Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin. J Invest Dermatol. 1994 Jan;102(1):122-4.
  15. Fuchs J, Huflejt ME, Rothfuss LM, Wilson DS, Carcamo G, Packer L. Impairment of enzymic 6 and nonenzymic antioxidants in skin by UVB irradiation. J Invest Dermatol. 1989 Dec; 93(6):769-73.
  16. Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev. 1998 Apr; 78(2):547-81.
  17. Pinnell SR. Cutaneous photodamage, oxidative stress and topical antioxidant protection. J Am Acad Dermatol. 2003 Jan:48(1):1-19; quiz 20-2.
  18. Chalopin M, Tesse A, Martinez MC, Rognan D, Arnal JF, Andriantsitohaina R. Estrogen receptor alpha as a key target of red wine polyphenols action on the endothelium. PLoS One. 2010 Jan 1;5(1):e8554.


Studies of Aloe Vera
  1. Moisturizing effect of cosmetic formulations containing Aloe vera extract in different concentrations assessed by skin bioengineering techniques. Laboratory of Cosmetic Technology, Faculdade de Ciencias Farmaceuticas de Ribeirão Pretõ, University of São Paulo, Brazil. http://www.ncbi.nlm.nih.gov/pubmed/17026654
  2. Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883372/.
  3. Aloe vera : A Potential Herb and its Medicinal Importance Journal of Chemical and Pharmaceutical Research http://jocpr.com/second-issue/J.%20Chem.%20Pharm.%20Res.,2010,%202(1) %2021-29.pdf.
  4. Aloe. University of Maryland Medical Center http://umm.edu/health/medical/altmed/herb/aloe.
  5. Tang Center for Herbal Medicine Research http://tangcenter.uchicago.edu/herbal_resources/aloe.shtml.
  6. Aloe vera: a systematic review of its clinical effectiveness British Journal of General Practice, October 1999 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1313538/pdf/10885091.pdf.
  7. Boudreau MD, Beland FA. An evaluation of the biological and toxicological properties of Aloe barbadensis (miller), Aloe vera. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2006 Apr;24(1):103-54.
  8. Capasso F, Borrelli F, Capasso R, et al. Aloe and its therapeutic use. Phytother Res. 1998;12:S124-S127.
  9. Fulton JE Jr. The stimulation of postdermabrasion wound healing with stabilized aloe vera gel-polyethylene oxide dressing. J Dermatol Surg Onco. 1990;16:460.
  10. Heggers J, et al. Beneficial effects of aloe in wound healing. Phytother Res. 1993; 7:S48-S52.
  11. Maenthaisong R, Chaiyakunapruk N, Niruntraporn S, Kongkaew C. The efficacy of aloe vera used for burn wound healing: a systematic review. Burns. 2007;33(6):713-8.
  12. Mantle D, Gok MA, Lennard TW. Adverse and beneficial effects of plant extracts on skin and skin disorders. Adverse Drug React Toxicol Rev. 2001;20(2):89-103.
  13. Paulsen E, Korsholm L, Brandrup F. A double-blind, placebo-controlled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris. J Eur Acad Dermatol Venereol. 2005 May;19(3):326-31.
  14. Reuter J, Jocher A, Stump J, Grossjohann B, Franke G, Schempp CM. Investigation of the anti-inflammatory potential of Aloe vera gel (97.5%) in the ultraviolet erythema test. Skin Pharmacol. Physiol. 2008;21(2):106-10.
  15. Saka WA, Akhhigbe RE, Ishola OS, Ashamu EA, Olayemi OT, Adeleke GE. Hepatotherapeutic effect of Aloe vera in alcohol-induced hepatic damage. Pak J Biol Sci. 2011; 14(14):742-6.
  16. Somboonwong J, Jariyapongskul A, Thanamittramanee S, et al. Therapeutic effects of aloe vera on cutaneous microcirculation and wound healing in second degree burn model in rats. J Med Assoc Thai. 2000;83:417-425.
  17. Vazquez B, et al. Anti-inflammatory activity of extracts from aloe vera gel. J Ethnopharmacol. 1996;55:69-75.
  18. Visuthikosol V, Sukwanarat Y, Chowchuen B, et al. Effect of aloe vera gel to healing of burn wound a clinical and histologic study. J Med Assoc Thai. 1995:78(8):402-408.


Studies on Collagen
  1. Collagen Type IITM Shown to Reverse Skin and Joint Aging http://www.vrp.com/bone-and-joint/bone-and-joint/collagen-type-ii-shown-to-reverse-skin-and-joint-aging.
  2. Collagen-like peptide exhibits a remarkable antiwrinkle effect on the skin when topically applied: in vivo study. 1Vincience Research Center, Sophia Antipolis, France. http://www.ncbi.nlm.nih.gov/pubmed/15648443.
  3. Collagen Stimulating Effect of Peptide Amphiphile C16-KTTKS on Human Fibroblasts, Monday 4 March by University of Reading. Molecular Pharmaceutics 2013 http://pubs.acs.org/doi/abs/10.1021/mp300549d?journalCode=mpohbp.
  4. Schwartz SR, Park J. Ingestion of BioCell Collagen, a novel hydrolyzed chicken sternal cartilage extract; enhance blood microcirculation and reduced facial aging signs. Clin Interv Aging. 2012;7:267-273. http://naturalmedicinejournal.com/journal/2013-10/effects-resveratrol-and-collagen-supplementation-facial-aging http://www.ncbi.nlm.nih.gov/pubmed/22956862.
  5. The study of absorption efficiency and restoring effects of collagen and ascorbic acid on aged skin by fluorescence and reflection spectroscopy. Guang Pu Xue Yu Guang Pu Fen Xi. 2012 Dec;32(12):3299-303. http://www.ncbi.nlm.nih.gov/pubmed/23427556.
  6. Duarte, A. The Collagen Type II Cure for Arthritis and Heart Disease. 1997:39.
  7. Oesser, S. & Seifert, J. Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen. Cell Tissue Res, 2003, 311:393-99.
  8. Novick, N. Tips for at-home anti-aging skin care. Total Health for Longevity, 2003, 25:44-46.
  9. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699641/
  10. Buonocore D, Lazzeretti A, Tosabens P, et al. Resveratrol-procyanidin blend: Nutraceutical and antiaging efficacy evaluated in a placebo-controlled, double-blind study. Clin Cosmet Investig Dermatol. 2012;2:159-165.
  11. Modified Collagen may stimulate cartilage re-growth study. Sept 21 2009 http://www.nutraingredients-usa.com/Research/Modified-collagen-may-stimulate-cartilage-re-growth-Study.
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