NaturaCel Research and Clinical StudiesStudies on Alpha Lipoic Acid
alpha-lipoic acid (LA) or the reduced form dihydrolipoate (DHLA) is a potent scavenger with anti-inflammatory properties. Previous uncontrolled studies with topical treatment with 5% LA-containing creams indicate a beneficial effect on photoageing skin.
The purpose of this study was to investigate whether a cream containing 5% LA showed any advantages concerning a number of the criteria associated with ageing of the facial skin, compared with an identical cream lacking LA.
Material and methods:
Thirty-three women, mean age 54.4 years, were included in this controlled study. After randomization half the face was treated twice daily for 12 weeks with the LA cream and the other half with the control cream. The following methods of assessment were used: self-evaluation by the test subjects, clinical evaluation, photographic evaluation and laser profilometry. Profilometry was performed before the start of treatment and at the end.
All four methods of assessment showed a statistically significant improvement on the LA-treated half of the face. Laser profilometry, the most objective method used, showed an average decrease in skin roughness of 50.8% (44.9-54.0) on the LA-treated side, compared with 40.7% (32.4-48.7) on the placebo-treated half of the face P < 0.001 (Wilcoxon matched pairs test).
It is indicated that 12 weeks of treatment with a cream containing 5% LA improves clinical characteristics related to photoageing of facial skin.
Department of Dermatology, Karolinska Hospital, 17176 Stockholm, Sweden.
Other Studies on Alpha Lipoic Acid
- Beitner H. Randomized, placebo controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol. 2003;149:841-9.
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- Alpha-lipoic acid | University of Maryland Medical Center
http://umm.edu/health/medical/altmed/supplement/alphalipoic-acid#ixzz38OWMjH6j University of Maryland Medical Center
Studies of Resveratrol
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- Available at: http://www.antioxidants-for-health-and-longevity.com/how-do-antioxidants-work.html. Accessed July 26, 2011.
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Studies of Aloe Vera
- Moisturizing effect of cosmetic formulations containing Aloe vera extract in different concentrations assessed by skin bioengineering techniques. Laboratory of Cosmetic Technology, Faculdade de Ciencias Farmaceuticas de Ribeirão Pretõ, University of São Paulo, Brazil. http://www.ncbi.nlm.nih.gov/pubmed/17026654
- Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883372/.
- Aloe vera : A Potential Herb and its Medicinal Importance Journal of Chemical and Pharmaceutical Research http://jocpr.com/second-issue/J.%20Chem.%20Pharm.%20Res.,2010,%202(1) %2021-29.pdf.
- Aloe. University of Maryland Medical Center http://umm.edu/health/medical/altmed/herb/aloe.
- Tang Center for Herbal Medicine Research http://tangcenter.uchicago.edu/herbal_resources/aloe.shtml.
- Aloe vera: a systematic review of its clinical effectiveness British Journal of General Practice, October 1999 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1313538/pdf/10885091.pdf.
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Studies on Collagen
- Collagen Type IITM Shown to Reverse Skin and Joint Aging http://www.vrp.com/bone-and-joint/bone-and-joint/collagen-type-ii-shown-to-reverse-skin-and-joint-aging.
- Collagen-like peptide exhibits a remarkable antiwrinkle effect on the skin when topically applied: in vivo study. 1Vincience Research Center, Sophia Antipolis, France. http://www.ncbi.nlm.nih.gov/pubmed/15648443.
- Collagen Stimulating Effect of Peptide Amphiphile C16-KTTKS on Human Fibroblasts, Monday 4 March by University of Reading. Molecular Pharmaceutics 2013 http://pubs.acs.org/doi/abs/10.1021/mp300549d?journalCode=mpohbp.
- Schwartz SR, Park J. Ingestion of BioCell Collagen, a novel hydrolyzed chicken sternal cartilage extract; enhance blood microcirculation and reduced facial aging signs. Clin Interv Aging. 2012;7:267-273. http://naturalmedicinejournal.com/journal/2013-10/effects-resveratrol-and-collagen-supplementation-facial-aging http://www.ncbi.nlm.nih.gov/pubmed/22956862.
- The study of absorption efficiency and restoring effects of collagen and ascorbic acid on aged skin by fluorescence and reflection spectroscopy. Guang Pu Xue Yu Guang Pu Fen Xi. 2012 Dec;32(12):3299-303. http://www.ncbi.nlm.nih.gov/pubmed/23427556.
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- Oesser, S. & Seifert, J. Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen. Cell Tissue Res, 2003, 311:393-99.
- Novick, N. Tips for at-home anti-aging skin care. Total Health for Longevity, 2003, 25:44-46.
- Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699641/
- Buonocore D, Lazzeretti A, Tosabens P, et al. Resveratrol-procyanidin blend: Nutraceutical and antiaging efficacy evaluated in a placebo-controlled, double-blind study. Clin Cosmet Investig Dermatol. 2012;2:159-165.
- Modified Collagen may stimulate cartilage re-growth study. Sept 21 2009 http://www.nutraingredients-usa.com/Research/Modified-collagen-may-stimulate-cartilage-re-growth-Study.
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